原位肝移植术后丙型肝炎复发感染的发生率及临床相关性。

Incidence and clinical relevance of recurrent hepatitis C infection after orthotopic liver transplantation.

作者信息

Knoop M, Lüsebrink R, Langrehr J M, König V, Berg T, Wedell A, Hopf U, Neuhaus P

机构信息

Department of Surgery, University Hospital Rudolf Virchow, Free University of Berlin, Germany.

出版信息

Transpl Int. 1994;7 Suppl 1:S221-3. doi: 10.1111/j.1432-2277.1994.tb01351.x.

DOI:10.1111/j.1432-2277.1994.tb01351.x

PMID:11271208

Abstract

From September 1988 to November 1992 318 liver transplants were performed at our hospital. Of these patients 68 had end-stage cirrhosis due to non-A, non-B, hepatitis, 44 of whom (64.7%) had hepatitis C virus RNA in the serum. Of this subgroup 35 patients (79.5%) were also anti-HCV positive. Postoperatively most recipients remained anti-HCV positive and after 1 year more than 90% had HCV RNA in the serum. About 40% developed a mild, chronic hepatitis and 50% were carriers of HCV without histopathological signs. Two patients suffered from a temporary severe acute hepatitis and one patient had a fulminant liver failure due to reinfection. In general, in liver recipients transplanted for end-stage HCV hepatitis there was a high incidence of reinfection with HCV. The clinical course, however, was less severe than in hepatitis B recurrence.

摘要

1988年9月至1992年11月，我院共进行了318例肝移植手术。这些患者中，68例因非甲非乙型肝炎导致终末期肝硬化，其中44例（64.7%）血清中检测到丙型肝炎病毒RNA。在这个亚组中，35例患者（79.5%）抗-HCV也呈阳性。术后大多数受者抗-HCV仍为阳性，1年后超过90%的患者血清中检测到HCV RNA。约40%的患者发展为轻度慢性肝炎，50%为HCV携带者，无组织病理学迹象。2例患者出现暂时性严重急性肝炎，1例患者因再次感染发生暴发性肝衰竭。总体而言，对于因终末期丙型肝炎接受肝移植的受者，HCV再次感染的发生率较高。然而，其临床过程比乙肝复发要轻。