Tzatzarakis M N, Tsatsakis A M, Lotter M M, Shtilman M I, Vakalounakis D J
Laboratory of Toxicology, Department of Medicine, University of Crete, Voutes 71409 Heraklion, Crete, Greece.
Food Addit Contam. 2000 Dec;17(12):965-71. doi: 10.1080/02652030010002289.
New controlled release water-soluble formulations of sorbic (2,4-hexadienoic) acid were prepared and their inhibitory activity on mycelium growth of Fusarium oxysporum f.sp. radicis-cucumerinum was evaluated. The new products are epoxidized polymers of polyvinylpyrrolidone (PVP) containing covalently bonded sorbic acid (polymeric esters of sorbic acid) and complexes of PVP with hydrogen bonded sorbic acid, characterized by controlled release of sorbic acid. It was shown that the polymeric complexes of sorbic acid with PVP were more effective fungicidal agents than sorbic acid polymeric esters. In all cases the activity of polymeric derivatives (esters and complexes) was increased by lowering the molecular weight of the polymeric carriers. Controlled release formulations of these polymeric derivatives are new promising products due to their low toxicity, wide range of efficient concentrations for application and ability to regulate lyophilicity. Our data contribute to the understanding of the action mechanism of various polymeric sorbic acid formulations and can result in products which are particularly suitable for food and feed protection applications.
制备了山梨酸（2,4 - 己二烯酸）的新型控释水溶性制剂，并评估了它们对黄瓜根腐尖孢镰刀菌菌丝体生长的抑制活性。新产品是含有共价键合山梨酸的聚乙烯吡咯烷酮（PVP）的环氧化聚合物（山梨酸的聚酯）以及PVP与氢键合山梨酸的络合物，其特征在于山梨酸的控释。结果表明，山梨酸与PVP的聚合物络合物比山梨酸聚酯是更有效的杀真菌剂。在所有情况下，通过降低聚合物载体的分子量，聚合物衍生物（酯和络合物）的活性都会增加。这些聚合物衍生物的控释制剂因其低毒性、广泛的有效应用浓度范围以及调节亲液性的能力而成为新的有前景的产品。我们的数据有助于理解各种聚合物山梨酸制剂的作用机制，并可产生特别适用于食品和饲料保护应用的产品。
