Suga K, Ishikawa Y, Matsunaga N, Tanaka N, Suda H, Handa T
Department of Radiology, Yamaguchi University School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi 755-8505, Japan.
Br J Radiol. 2000 Oct;73(874):1115-9. doi: 10.1259/bjr.73.874.11271908.
Abnormal hepatic haemodynamics and function in a 43-year-old woman with hereditary haemorrhagic telangiectasia (HHT) were evaluated using 99Tcm-phytate angiography and iodine-123-iodoamphetamine transrectal portal scintigraphy. Radionuclide angiography demonstrated hyperdynamic perfusion of the liver owing to intrahepatic arteriovenous fistulae (AVF), entry of tracer into the systemic circulation through intrahepatic portosystemic shunts and an increase in recirculating blood flow caused by these vascular disorders. Heterogeneous distribution of tracer also suggested the presence of chronic hepatic injury. Transrectal portal scintigraphy showed large portosystemic shunts. Other imaging techniques confirmed the presence of the AVF but failed to identify the portosystemic shunts. Non-invasive radionuclide studies are helpful in the evaluation of hepatic involvement of HHT.
采用99锝-植酸盐血管造影术和碘-123-碘安非他明经直肠门静脉闪烁扫描术，对一名43岁遗传性出血性毛细血管扩张症（HHT）女性患者的肝脏血流动力学和功能异常进行了评估。放射性核素血管造影显示，由于肝内动静脉瘘（AVF），肝脏呈高动力灌注，示踪剂通过肝内门体分流进入体循环，并且这些血管疾病导致再循环血流增加。示踪剂的不均匀分布也提示存在慢性肝损伤。经直肠门静脉闪烁扫描显示存在大量门体分流。其他成像技术证实了AVF的存在，但未能识别出门体分流。非侵入性放射性核素研究有助于评估HHT的肝脏受累情况。
