Br J Neurosurg. 2000 Dec;14(6):525-30. doi: 10.1080/02688690020005527.
The Working Party was instituted to investigate the rationale of therapeutic antibiotic usage in patients with brain abscess and to make recommendations for current practice. A systematic review of English language publications on brain abscess over the last 25 years was carried out using electronic databases and secondary sources, and data were evaluated. Few publications were identified where the microbiological procedures were adequately described and many authors continue to report sterile pus in a proportion of cases. The vast majority of reports were retrospective neurosurgical assessments in which details of laboratory procedures and antibiotic regimens were missing. There are no published reports of controlled clinical trials or comparative therapeutic studies. The recommendations made by the Working Party are based on relevant published information and the expertise of Working Party members. Recommendations vary according to the location of the abscess which reflects the likely source of the infection and therefore the bacterial types most likely to be present in aspirated pus. Bacteria with multiple resistance to antimicrobial agents do not feature significantly in cases of brain abscess.
成立该工作小组的目的是调查脑脓肿患者使用治疗性抗生素的基本原理，并为当前的治疗实践提供建议。我们使用电子数据库和二手资料，对过去25年里关于脑脓肿的英文出版物进行了系统综述，并对数据进行了评估。发现很少有出版物充分描述了微生物学程序，而且许多作者继续报告在一定比例的病例中脓液无菌。绝大多数报告是回顾性神经外科评估，其中缺少实验室程序和抗生素治疗方案的细节。没有关于对照临床试验或比较治疗研究的发表报告。工作小组提出的建议基于相关的已发表信息和工作小组成员的专业知识。建议因脓肿的位置而异，这反映了感染的可能来源，因此也反映了抽吸脓液中最可能存在的细菌类型。对多种抗菌药物具有耐药性的细菌在脑脓肿病例中并不显著。
