Inoue H
Department of Surgery, Tokyo Medical and Dental University, Japan.
Endoscopy. 2001 Feb;33(2):119-25. doi: 10.1055/s-2001-11664.
In the diagnosis of early cancer, there are differences in the pathological criteria used by Western and Asian (Japanese) pathologists. The Vienna classification advocated by pathologists offers standard pathological criteria common to all endoscopists, and it has clarified the indications for the treatment of superficial lesions, including high-grade dysplasia and mucosal cancer. Endoscopic mucosal resection (EMR) is increasingly being used in the treatment of early cancer. Experience with EMR in the treatment of Barrett's esophagus with cancer has been reported, and the preliminary results are encouraging. Some technical variations and improvements in EMR procedures have been described. As an injection agent, the use of mucinous substances such as sodium hyaluronate has been reported. A cutting knife with an insulated tip has been designed, making the use of the precutting technique much safer. Studies have been conducted comparing the freehand technique with the cap technique for EMR, and it was found that the cap technique is generally better. Ablative treatment has also been used in many cases, with satisfactory results. In advanced cancer, self-expanding metallic stents have been used for palliative treatment, with generally satisfactory results. The range of applications for therapeutic endoscopy has continued to expand during the last two years in the treatment of esophageal and gastric tumors.
在早期癌症的诊断中,西方病理学家和亚洲(日本)病理学家所采用的病理标准存在差异。病理学家倡导的维也纳分类法为所有内镜医师提供了通用的标准病理标准,并且明确了包括高级别异型增生和黏膜癌在内的浅表病变的治疗指征。内镜黏膜切除术(EMR)在早期癌症治疗中的应用越来越广泛。已有关于EMR治疗伴有癌症的巴雷特食管的经验报道,初步结果令人鼓舞。也有文献描述了EMR操作中的一些技术变化和改进。作为一种注射剂,已有使用透明质酸钠等黏液性物质的报道。一种带有绝缘尖端的切割刀已被设计出来,使得预切割技术的使用更加安全。已有研究对EMR的徒手技术和套扎技术进行了比较,发现套扎技术总体上更好。消融治疗在许多病例中也有应用,效果令人满意。在晚期癌症中,自膨式金属支架已用于姑息治疗,总体效果令人满意。在过去两年中,治疗性内镜在食管和胃肿瘤治疗中的应用范围持续扩大。