Kholkute S D, Nandedkar T D, Puri C P
Institute for Research in Reproduction (ICMR) Jehangir Merwanji Street, Mumbai 400 012, India.
Indian J Exp Biol. 2000 May;38(5):425-31.
In the present study, changes in the immunohistochemical localization of endometrial estrogen receptor (ER) and progesterone receptor (PR) during various stages of the ovarian cyclicity in common marmoset, have been reported. Ovarian cyclicity was monitored by estimating plasma estradiol and progesterone. During the early follicular phase, weak ER immunolocalization was observed in the endometrial stroma. During the late follicular phase under the influence of rising estradiol levels, stromal ER localization was intense. During the luteal phase, ER localization was absent in the stroma indicating that high concentrations of progesterone suppressed ER. PR localization was not observed in the stroma during the early follicular phase, while weak staining was seen in the stroma during the late follicular phase. PR localization was maximum during the mid luteal phase. However in marmoset, endometrial ER and PR localization was restricted only to the stroma. This unique feature may be due to the characteristic reproductive profile of this nonmenstruating species and needs to be studied further. Thus it can be hypothesized that in the marmoset endometrium, steroid hormone mediated effects possibly occur directly in the stroma and are then transmitted to the epithelium by autocrine/paracrine action of growth factors and cytokines.
在本研究中，已报道了普通狨猴卵巢周期各阶段子宫内膜雌激素受体（ER）和孕激素受体（PR）免疫组化定位的变化。通过测定血浆雌二醇和孕酮来监测卵巢周期。在卵泡早期，子宫内膜基质中观察到弱的ER免疫定位。在卵泡晚期，受雌二醇水平升高影响，基质中ER定位强烈。在黄体期，基质中未观察到ER定位，表明高浓度孕酮抑制了ER。在卵泡早期，基质中未观察到PR定位，而在卵泡晚期，基质中可见弱染色。PR定位在黄体中期最大。然而在狨猴中，子宫内膜ER和PR定位仅局限于基质。这种独特特征可能归因于这种非月经物种的特征性生殖模式，需要进一步研究。因此可以推测，在狨猴子宫内膜中，类固醇激素介导的效应可能直接在基质中发生，然后通过生长因子和细胞因子的自分泌/旁分泌作用传递给上皮细胞。
