Lopes Reginaldo Guedes C, Baracat Edmund Chada, de Albuquerque Neto Luiz Cavalcanti, Ramos José Francisco Dória, Yatabe Salete, Depesr Daniela Baptista, Lippi Umberto Gazi
Service of Gynecology and Obstetrics, Servidor Público Estadual de São Paulo Hospital, Francisco Morato de Oliveira, Sao Paulo, Brazil.
J Minim Invasive Gynecol. 2007 May-Jun;14(3):300-3. doi: 10.1016/j.jmig.2006.10.022.
To investigate the presence of estrogen receptors (ER) and progesterone receptors (PR) in the glandular epithelium and stroma of endometrial polyps in women who underwent hysteroscopic polypectomy.
Prospective study (Canadian Task Force classification II-3.
Hospital de Servidor Público Estadual de São Paulo "Francisco Morato de Oliveira."
Forty-eight patients with a solitary endometrial polyp who underwent hysteroscopic polypectomy and resection of an endometrial fragment.
The estrogen and progesterone receptor expression, in the polyp, was compared with the endometrial hormone expression of the same patients.
The specimens were analyzed by immunohistochemistry. The percentage of staining cells was determined as follows: grade I, 0% to 25%; grade II, 26% to 50%; grade III, 51% to 75%; and grade IV, 76% to 100% of stained nuclei. The intensity of nuclear staining was classified as grade I, absent; grade II, weak; grade III, strong; and grade IV, very strong staining. The sum of both grades was the histochemical score. The total scores of polyp and endometrium were statistically compared. The total scores of ER of glandular epithelium were 258 in polyp and 211 in endometrium. As to stroma, it was 155 in polyp and 163 in endometrium. The total scores of PR of glandular epithelium were 286 in polyp and 211 in endometrium. As to stroma, the totals were 76 in polyp and 77 in endometrium. In immunohistochemistry, the concentrations of both ER and PR in glandular epithelium were significantly higher in endometrial polyp than in normal endometrium. The concentrations of ER and PR in the stroma were similar in the polyp and endometrium. The concentrations of these receptors in the glandular epithelium and stroma were similar in postmenopausal and premenopausal patients.
The concentrations of ER and PR in glandular epithelium were significantly higher in endometrial polyp than in normal endometrium. The concentrations of these receptors in the glandular epithelium and stroma were similar in the postmenopausal and pre-menopausal patients.
调查接受宫腔镜息肉切除术的女性子宫内膜息肉的腺上皮和间质中雌激素受体（ER）和孕激素受体（PR）的存在情况。
前瞻性研究（加拿大工作组分类II-3）。
圣保罗州立公立医院“弗朗西斯科·莫拉托·德奥利维拉医院”。
48例患有单个子宫内膜息肉并接受宫腔镜息肉切除术及子宫内膜碎片切除术的患者。
将息肉中的雌激素和孕激素受体表达与同一患者的子宫内膜激素表达进行比较。
标本采用免疫组织化学分析。染色细胞百分比的确定如下：I级，0%至25%；II级，26%至50%；III级，51%至75%；IV级，76%至100%的细胞核染色。细胞核染色强度分为I级，无；II级，弱；III级，强；IV级，极强染色。两个等级之和为组织化学评分。对息肉和子宫内膜的总分进行统计学比较。腺上皮ER的总分在息肉中为258，在子宫内膜中为211。至于间质，息肉中为155，子宫内膜中为163。腺上皮PR的总分在息肉中为286，在子宫内膜中为211。至于间质，息肉中总计为76，子宫内膜中为77。在免疫组织化学中，子宫内膜息肉腺上皮中ER和PR的浓度均显著高于正常子宫内膜。息肉和子宫内膜中间质中ER和PR的浓度相似。绝经后和绝经前患者腺上皮和间质中这些受体的浓度相似。
子宫内膜息肉腺上皮中ER和PR的浓度显著高于正常子宫内膜。绝经后和绝经前患者腺上皮和间质中这些受体的浓度相似。
