Davie J R, Moniwa M
Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada.
Crit Rev Eukaryot Gene Expr. 2000;10(3-4):303-25. doi: 10.1615/critreveukargeneexpr.v10.i3-4.70.
Chromatin structure has a pivotal role in the regulation of gene expression. Transcriptional activation or the repression of a gene require the recruitment of multiple chromatin remodeling complexes. Chromatin remodeling complexes modulate the higher order structure of chromatin, facilitate or hinder the binding of transcription factors, and aid in or prevent the establishment of a transcriptional preinitiation complex. Two types of chromatin remodeling complexes have been extensively studied--ATP-dependent chromatin remodeling complexes and histone-modifying enzymes--which include histone acetyltransferases, histone deacetylases, and histone kinases. Transcriptional activators and repressors are responsible for recruitment of one or more of these large, multisubunit chromatin remodeling complexes. In this review, the features of the chromatin remodeling complexes and the modes of their recruitment are presented.
染色质结构在基因表达调控中起关键作用。基因的转录激活或抑制需要募集多种染色质重塑复合物。染色质重塑复合物调节染色质的高级结构，促进或阻碍转录因子的结合，并有助于或阻止转录起始前复合物的形成。两类染色质重塑复合物已得到广泛研究——ATP依赖性染色质重塑复合物和组蛋白修饰酶——其中包括组蛋白乙酰转移酶、组蛋白去乙酰化酶和组蛋白激酶。转录激活因子和抑制因子负责募集这些大型多亚基染色质重塑复合物中的一种或多种。在本综述中，将介绍染色质重塑复合物的特征及其募集方式。
