Friel K M, Heddings A A, Nudo R J
Department of Molecular and Integrative Physiology, Mental Retardation Research Center, Kansas City, Kansas, USA.
Neurorehabil Neural Repair. 2000;14(3):187-98. doi: 10.1177/154596830001400304.
Previous studies have shown that after injury to the hand representation in primary motor cortex (M1), size of the spared hand representation decreased dramatically unless the unimpaired hand was restrained and monkeys received daily rehabilitative training using the impaired fingers. The goal of this study was to determine if restriction of the unimpaired hand was sufficient to retain spared hand area after injury or if retention of the spared area required repetitive use of the impaired limb. After infarct to the hand area of M1 in adult squirrel monkeys, the unimpaired hand was restrained by a mesh sleeve over the unimpaired arm. Monkeys did not receive rehabilitative training. Electrophysiologic maps of M1 were derived in anesthetized monkeys before infarct and 1 month after infarct by using intracortical microstimulation. One month after the lesion, the size of the hand representation had decreased. Areal changes were significantly smaller than those in animals in a previous study that had received daily repetitive training after infarct (p < 0.05). Areal changes were not different from those in a group of animals that received neither rehabilitative intervention nor hand restraint after injury. These results suggest that retention of hand area in M1 after a lesion requires repetitive use of the impaired hand.
先前的研究表明，在初级运动皮层（M1）手部代表区受损后，若未受损的手未受限制且猴子未接受使用受损手指的每日康复训练，那么未受损手部代表区的大小会急剧减小。本研究的目的是确定限制未受损的手是否足以在损伤后保留未受损手部区域，或者保留未受损区域是否需要反复使用受损肢体。在成年松鼠猴的M1手部区域梗死之后，用网状套筒套住未受损的手臂来限制未受损的手。猴子未接受康复训练。通过皮层内微刺激在梗死前和梗死1个月后对麻醉的猴子进行M1的电生理图谱绘制。损伤1个月后，手部代表区的大小减小了。面积变化显著小于先前研究中梗死之后接受每日重复训练的动物（p < 0.05）。面积变化与损伤后既未接受康复干预也未进行手部限制的一组动物没有差异。这些结果表明，损伤后M1中手部区域的保留需要反复使用受损的手。
