Hegab A M, Luketic V A
Division of Gastoenterology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Postgrad Med. 2001 Feb;109(2):75-6, 81-6, 89. doi: 10.3810/pgm.2001.02.852.
Bleeding esophageal varices, one of the most feared complications of portal hypertension, contribute to the estimated 32,000 deaths annually attributed to cirrhosis. Successful control requires knowledge of the pertinent anatomy, underlying pathophysiology of portal hypertension, and natural history of gastro-esophageal varices. Drs Hegab and Luketic review these topics and discuss the various prophylactic and therapeutic approaches to management, including pharmacologic agents, endoscopic sclerotherapy, and trans-jugular intrahepatic portosystemic shunt (TIPS).
食管静脉曲张破裂出血是门静脉高压最可怕的并发症之一，据估计每年因肝硬化导致的32000例死亡与之相关。成功控制出血需要了解相关解剖结构、门静脉高压的潜在病理生理学以及胃食管静脉曲张的自然病程。赫加布博士和卢凯蒂克博士回顾了这些主题，并讨论了各种预防性和治疗性管理方法，包括药物、内镜硬化治疗和经颈静脉肝内门体分流术（TIPS）。
