Madan Z M, Sainani G S
Jaslok Hospital and Research Centre.
J Assoc Physicians India. 2000 Jun;48(6):581-3.
The aim of this study was to find out the effects of cyclo-oxygenase and thromboxane synthetase inhibitors on right atrial prostacyclin and thromboxane A2 levels.
The study consisted of a total of 50 patients subjected to coronary bypass surgery. These patients were divided into two groups, Group I and Group II each consisting of 25 patients. In Group I patients, the right atrial tissues were studied for effects of indomethacin and U63557A on the prostaglandin levels. In Group II patients, the right atrial tissues were studied for effects of Aspirin and U63557A on the prostaglandin levels.
In Group I patients, the atrial tissues pretreated with indomethacin showed a fall in the levels of 6 keto PGF1 alpha from 153.5 +/- 28.4 pg/0.1 mg to 59.7 +/- 11.6 pg/0.1 mg and of TXB2 from 41.6 +/- 1.2 pg/0.1 mg to 17.2 +/- 3.2 pg/0.1 mg. In the atrial tissues of Group I treated with U63557A the levels of 6 keto PGF1 alpha fell to 145.4 +/- 26.8 pg/0.1 mg and the levels of TXB2 fell to 14.7 +/- 2.8 pg/0.1 mg. In Group II patients, the atrial tissues pretreated with aspirin, showed a fall in the levels of 6 keto PGF1 alpha from 142.1 +/- 2.8 pg/0.1 mg to 17.5 +/- 0.8 pg/0.1 mg. In the atrial tissues pretreated with U63557A, the levels of 6 keto PGF1 alpha fell to 131.2 +/- 2.9 pg/0.1 mg and the levels of TXB2 fell to 14.4 +/- 0.7 pg/0.1 mg.
The study showed that human right atrial tissues are capable of producing TXA2 in addition to prostacyclin. Indomethacin and aspirin by inhibiting generation of cyclic endoperoxides inhibited synthesis of both prostacyclin and TXA2. In contrast a thromboxane synthethase inhibitor U63557A selectively inhibited TXA2 without significant effects on prostacyclin synthesis.
本研究旨在探究环氧化酶和血栓素合成酶抑制剂对右心房前列环素和血栓素A2水平的影响。
本研究共纳入50例行冠状动脉搭桥手术的患者。这些患者被分为两组，每组25例。在第一组患者中，研究吲哚美辛和U63557A对右心房组织中前列腺素水平的影响。在第二组患者中，研究阿司匹林和U63557A对右心房组织中前列腺素水平的影响。
在第一组患者中，用吲哚美辛预处理的心房组织中，6-酮-前列环素F1α水平从153.5±28.4 pg/0.1 mg降至59.7±11.6 pg/0.1 mg，血栓素B2水平从41.6±1.2 pg/0.1 mg降至17.2±3.2 pg/0.1 mg。在用U63557A处理的第一组心房组织中，6-酮-前列环素F1α水平降至145.4±26.8 pg/0.1 mg，血栓素B2水平降至14.7±2.8 pg/0.1 mg。在第二组患者中，用阿司匹林预处理的心房组织中，6-酮-前列环素F1α水平从142.1±2.8 pg/0.1 mg降至17.5±0.8 pg/0.1 mg。在用U63557A预处理的心房组织中，6-酮-前列环素F1α水平降至131.2±2.9 pg/0.1 mg，血栓素B2水平降至14.4±0.7 pg/0.1 mg。
该研究表明，人类右心房组织除了能产生前列环素外，还能产生血栓素A2。吲哚美辛和阿司匹林通过抑制环内过氧化物的生成，抑制了前列环素和血栓素A2的合成。相比之下，血栓素合成酶抑制剂U63557A选择性地抑制了血栓素A2，而对前列环素合成没有显著影响。
