实验性自身免疫性肌无力：大鼠和豚鼠重症肌无力模型
Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.
作者信息
Lennon V A, Lindstrom J M, Seybold M E
出版信息
J Exp Med. 1975 Jun 1;141(6):1365-75. doi: 10.1084/jem.141.6.1365.
Abstract
Immunization of animals with acetylcholine receptor (AChR) protein from the electric organs of Electrophorus electricus and Torpedo californica induces an autoimmune response to the AChR of mammalian skeletal muscle. Rats and guinea pigs develop experimental autoimmune myasthenia gravis (EAMG) after a single inoculation with small quantities of AChR and adjuvant. The indicence and severity of disease appears to depend on the dose of AChR and stability of the emulsion. EAMG is strikingly similar to myasthenia gravis (MG) of man in its clinical picture and its electrophysiological abnormalities. The presence of antibodies to syngeneic rat muscle AChR in the serum of rats with EAMG documents the existence of autoimmunity in the experimental disease. A common immunopathogenesis is suggested for both EAMG and mg.
摘要
用来自电鳗（Electrophorus electricus）和加州电鳐（Torpedo californica）电器官的乙酰胆碱受体（AChR）蛋白对动物进行免疫接种，会引发针对哺乳动物骨骼肌AChR的自身免疫反应。大鼠和豚鼠在单次接种少量AChR和佐剂后会患上实验性自身免疫性重症肌无力（EAMG）。疾病的发病率和严重程度似乎取决于AChR的剂量和乳剂的稳定性。EAMG在临床表现和电生理异常方面与人类重症肌无力（MG）极为相似。患有EAMG的大鼠血清中存在针对同基因大鼠肌肉AChR的抗体，这证明了实验性疾病中自身免疫的存在。有人提出EAMG和MG具有共同的免疫发病机制。
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