空肠弯曲菌的等位基因多样性与重组
Allelic diversity and recombination in Campylobacter jejuni.
作者信息
Suerbaum S, Lohrengel M, Sonnevend A, Ruberg F, Kist M
机构信息
Institut für Hygiene und Mikrobiologie der Universität Würzburg, D-97080 Würzburg, Germany.
出版信息
J Bacteriol. 2001 Apr;183(8):2553-9. doi: 10.1128/JB.183.8.2553-2559.2001.
Abstract
The allelic diversity and population structure of Campylobacter jejuni were studied by multilocus nucleotide sequence analysis. Sequences from seven housekeeping genes were obtained from 32 C. jejuni isolates isolated from enteritis patients in Germany, Hungary, Thailand, and the United States. Also included was strain NCTC 11168, the complete genomic sequence of which has recently been published. For all loci analyzed, multiple strains carried identical alleles. The frequency of synonymous and nonsynonymous sequence polymorphisms was low. The number of unique alleles per locus ranged from 9 to 15. These alleles occurred in 31 different combinations (sequence types), so that all but two pairs of strains could be distinguished from each other. Sequences were analyzed for evidence of recombination by the homoplasy test and split decomposition. These analyses showed that intraspecific recombination is frequent in C. jejuni and has generated extensive diversity of allelic profiles from a small number of polymorphic nucleotides.
摘要
通过多位点核苷酸序列分析研究了空肠弯曲菌的等位基因多样性和群体结构。从德国、匈牙利、泰国和美国的肠炎患者分离出的32株空肠弯曲菌中获得了7个管家基因的序列。还包括NCTC 11168菌株，其完整基因组序列最近已发表。对于所有分析的位点，多个菌株携带相同的等位基因。同义及非同义序列多态性的频率较低。每个位点独特等位基因的数量在9至15个之间。这些等位基因以31种不同的组合（序列类型）出现，因此除了两对菌株外，所有菌株都可以相互区分。通过同塑检验和分裂分解分析序列以寻找重组证据。这些分析表明，空肠弯曲菌种内重组频繁，并且从少量多态性核苷酸产生了广泛的等位基因谱多样性。
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