Bosco G, Poppele R E
Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA. .
Physiol Rev. 2001 Apr;81(2):539-68. doi: 10.1152/physrev.2001.81.2.539.
This review explores how proprioceptive sensory information is organized at spinal cord levels as it relates to a sense of body position and movement. The topic is considered in an historical context and develops a different framework that may be more in tune with current views of sensorimotor processing in other central nervous system structures. The dorsal spinocerebellar tract (DSCT) system is considered in detail as a model system that may be considered as an end point for the processing of proprioceptive sensory information in the spinal cord. An analysis of this system examines sensory processing at the lowest levels of synaptic connectivity with central neurons in the nervous system. The analysis leads to a framework for proprioception that involves a highly flexible network organization based in some way on whole limb kinematics. The functional organization underlying this framework originates with the biomechanical linkages in the limb that establish functional relationships among the limb segments. Afferent information from limb receptors is processed further through a distributed neural network in the spinal cord. The result is a global representation of hindlimb parameters rather than a muscle-by-muscle or joint-by-joint representation.
本综述探讨本体感觉信息在脊髓水平上是如何与身体位置和运动感觉相关联而进行组织的。该主题在历史背景下进行了考量，并构建了一个可能更符合当前对其他中枢神经系统结构中感觉运动处理观点的不同框架。背侧脊髓小脑束（DSCT）系统作为一个模型系统被详细探讨，它可被视为脊髓中本体感觉信息处理的终点。对该系统的分析考察了与神经系统中枢神经元突触连接最低水平的感觉处理。该分析得出了一个本体感觉框架，该框架涉及以某种方式基于整个肢体运动学的高度灵活的网络组织。这个框架背后的功能组织源于肢体中的生物力学联系，这些联系在肢体节段之间建立了功能关系。来自肢体感受器的传入信息通过脊髓中的分布式神经网络进一步处理。结果是后肢参数的全局表示，而不是逐个肌肉或逐个关节的表示。
