Langerman L, Piscoun B, Bansinath M, Shemesh Y, Turndorf H, Grant G J
The Department of Anesthesiology, New York University Medical Center, 550 First Ave., New York, NY 10016, USA.
Pharmacol Biochem Behav. 2001 Jan;68(1):1-6. doi: 10.1016/s0091-3057(00)00442-1.
We evaluated the intensity of the withdrawal symptoms after the discontinuation of the morphine infusion in rats. Opiate addiction was induced by progressively increasing intraperitoneal morphine infusion rates. The control group (Group 1) received normal saline. The initial morphine rates were 1, 4, and 16 mg kg(-1) h for Groups 2, 3, and 4, respectively. Infusion rates were gradually increased by a factor of 1.4, 2, 2.8, and 4 on the second, third, fourth, and fifth days, respectively. The last rate was used for 48 h and then infusions were disconnected. Weight reduction, food consumption, and water intake were used for evaluation of withdrawal. All morphine groups showed a significant reduction of body weight during the 4 postdiscontinuation days and a decline in food and water intake on the first postdiscontinuation day. All changes were dependent on the morphine infusion concentration. No changes were observed in the control group. We suggest that the rat model used in this study may be utilized for quantification of spontaneous withdrawal.
我们评估了大鼠停止输注吗啡后戒断症状的强度。通过逐步提高腹腔内吗啡输注速率来诱导阿片类成瘾。对照组（第1组）接受生理盐水。第2、3和4组的初始吗啡输注速率分别为1、4和16 mg kg⁻¹ h。在第2、3、4和5天，输注速率分别逐渐提高1.4、2、2.8和4倍。最后一个速率持续使用48小时，然后停止输注。通过体重减轻、食物消耗和水摄入量来评估戒断情况。所有吗啡组在停止输注后的4天内体重均显著减轻，且在停止输注后的第一天食物和水摄入量下降。所有变化均取决于吗啡输注浓度。对照组未观察到变化。我们认为本研究中使用的大鼠模型可用于定量自发戒断。
