McDonald Robert V, Siegel Shepard
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
Exp Clin Psychopharmacol. 2004 Feb;12(1):3-11. doi: 10.1037/1064-1297.12.1.3.
On the basis of a conditioning analysis, some drug "withdrawal symptoms" are conditional responses elicited by stimuli paired with the drug effect. Prior demonstrations of conditional elicitation of withdrawal symptoms evaluated the role of environmental cues; however, pharmacological cues also typically signal a drug effect. Within each administration, early drug onset cues (DOCs) may become associated with the later, larger drug effect (intra-administration associations). This experiment evaluated the contribution of intra-administration associations to withdrawal symptoms. The results indicated that (a). 5 mg/kg morphine elicited behavioral and thermic withdrawal symptoms in rats previously injected on a number of occasions with 50 mg/kg morphine and that (b). DOC-elicited withdrawal symptoms are not a sensitized response to the opiate but rather an associative phenomenon.
基于条件分析，一些药物“戒断症状”是与药物效应配对的刺激所引发的条件反应。先前关于戒断症状条件引发的研究评估了环境线索的作用；然而，药理学线索通常也标志着药物效应。在每次给药过程中，早期药物起效线索（DOCs）可能会与后来更强的药物效应产生关联（给药内关联）。本实验评估了给药内关联对戒断症状的影响。结果表明：（a）. 5毫克/千克吗啡在先前多次注射50毫克/千克吗啡的大鼠中引发了行为和体温戒断症状；以及（b）. DOC引发的戒断症状并非对阿片类药物的敏感化反应，而是一种关联现象。
