Asakawa H, Tokunaga K, Kawakami F
Department of Internal Medicine, Itami City Hospital, 1-100, Koyaike, Itami, Hyogo 664-8540, Japan.
J Diabetes Complications. 2001 Mar-Apr;15(2):57-62. doi: 10.1016/s1056-8727(00)00145-8.
Leptin is considered to play an important role in the regulation of body weight and metabolism in obese individuals. However, the relationship of leptin with metabolic disorders or vascular complications in type 2 diabetic patients has yet to be elucidated. In this study, we investigated the association of leptin levels with clinical parameters (glycemic control, lipid levels, abdominal fat distribution) and investigated the leptin levels of diabetic patients with and without vascular complications in Japanese diabetic patients. In male and female patients, leptin levels were significantly associated with body mass index (BMI), percent body fat, insulin level, triglyceride (TG) level, total abdominal fat area (TFA), visceral fat area (VFS), and subcutaneous fat area (SFA). Only in male patients, leptin levels were inversely correlated with HDL-cholesterol, fasting plasma glucose (FPG), and HbA(1C). Leptin levels in male and female patients with hypertension were higher than in those without hypertension. Leptin levels of both males and females with angiopathy were not statistically different from those without angiopathy. In conclusion, leptin is involved in various metabolic disorders and hypertension, and we speculate that it may not be strongly associated with vascular complications in Japanese diabetic individuals.
瘦素被认为在肥胖个体的体重和代谢调节中起重要作用。然而，瘦素与2型糖尿病患者代谢紊乱或血管并发症之间的关系尚未阐明。在本研究中，我们调查了瘦素水平与临床参数（血糖控制、血脂水平、腹部脂肪分布）之间的关联，并调查了日本糖尿病患者中有无血管并发症的糖尿病患者的瘦素水平。在男性和女性患者中，瘦素水平与体重指数（BMI）、体脂百分比、胰岛素水平、甘油三酯（TG）水平、总腹部脂肪面积（TFA）、内脏脂肪面积（VFS）和皮下脂肪面积（SFA）显著相关。仅在男性患者中，瘦素水平与高密度脂蛋白胆固醇、空腹血糖（FPG）和糖化血红蛋白（HbA1C）呈负相关。患有高血压的男性和女性患者的瘦素水平高于未患高血压的患者。患有血管病变的男性和女性的瘦素水平与未患血管病变的患者在统计学上无差异。总之，瘦素与各种代谢紊乱和高血压有关，我们推测它可能与日本糖尿病个体的血管并发症没有密切关联。
