Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
J Int Med Res. 2024 Aug;52(8):3000605241270648. doi: 10.1177/03000605241270648.
To investigate the possible association of periorbital melanosis (POM) with insulin resistance (IR) and vitamin D serum levels.
In this pilot, case-control study, we included 100 adult patients with POM and 100 age- and sex-matched healthy control subjects. Vitamin D levels and IR indices (i.e., homeostatic model assessment-insulin resistance [HOMA-IR], triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) ratio, adiponectin/leptin (A/L) ratio) were compared between cases and controls.
Compared with controls, POM cases had significantly higher values of HOMA-IR and TG/HDL-c ratio, and significantly lower values of A/L and vitamin D. HOMA-IR and TG/HDL-c ratio were statistically significantly positively correlated with POM severity while Vitamin D and A/L ratio were statistically significantly negatively correlated.
POM was associated with indices of IR and vitamin D deficiency. However, the exact causal link among POM, IR, and vitamin D needs to be established. However, the results of this pilot study suggest that POM may have potential as a cutaneous non-invasive marker of these metabolic disorders which would assist in detecting and treating them at an early stage.
探讨眶周黑色素沉着（POM）与胰岛素抵抗（IR）和维生素 D 血清水平之间可能存在的关联。
在这项初步的病例对照研究中，我们纳入了 100 例成人 POM 患者和 100 例年龄和性别匹配的健康对照者。比较了病例组和对照组之间的维生素 D 水平和 IR 指数（即稳态模型评估-胰岛素抵抗[HOMA-IR]、甘油三酯/高密度脂蛋白胆固醇（TG/HDL-c）比值、脂联素/瘦素（A/L）比值）。
与对照组相比，POM 患者的 HOMA-IR 和 TG/HDL-c 比值明显更高，A/L 和维生素 D 水平明显更低。HOMA-IR 和 TG/HDL-c 比值与 POM 严重程度呈统计学显著正相关，而维生素 D 和 A/L 比值与 POM 严重程度呈统计学显著负相关。
POM 与 IR 和维生素 D 缺乏的指数有关。然而，POM、IR 和维生素 D 之间的确切因果关系尚需建立。然而，这项初步研究的结果表明，POM 可能是这些代谢紊乱的一种皮肤非侵入性标志物，有助于早期发现和治疗这些紊乱。
