Sherman J O, Hamly C A, Khachadurina A K
J Pediatr. 1975 Apr;86(4):518-23. doi: 10.1016/s0022-3476(75)80140-5.
Twenty-seven infants from 1 day to 9 months of age with severe intractable diarrhea were fed an oral elemental diet (Vivonex) consisting of crystalline amino acids, glucose, electrolytes, and vitamins by continuous nasogastric drip. Complete control of diarrhea was achieved in 24 patients (89 percent) who had an average weight gain of 28 gm/day. Nitrogen balance and plasma amino acids were measured in five patients while they received 2.25 gm of amino acid/kd/day for two weeks and 4.58 gm of amino acid/kg/day for two weeks; the nitrogen balance and weight gain in three patients was proportional to the amino acid intake. When compared to normal levels, plasma amino acids were not appreciably increased with the lower amino acid intake. With the higher amino acid intake, there were significant increases in plasma values for 11 amino acids.
对27例年龄在1日龄至9个月的患有严重顽固性腹泻的婴儿，通过持续鼻胃管滴注给予一种由结晶氨基酸、葡萄糖、电解质和维生素组成的口服要素饮食（Vivonex）。24例患者（89%）腹泻得到完全控制，平均体重增加28克/天。对5例患者在接受2.25克氨基酸/千克/天两周以及4.58克氨基酸/千克/天两周时测定了氮平衡和血浆氨基酸；3例患者的氮平衡和体重增加与氨基酸摄入量成正比。与正常水平相比，较低氨基酸摄入量时血浆氨基酸没有明显增加。较高氨基酸摄入量时，11种氨基酸的血浆值显著增加。
