Fournier C, Kourrich S, Soumireu-Mourat B, Mourre C
Laboratoire de Neurobiologie des Comportements, UMR 6562, CNRS-Université de Provence, IBHOP, Traverse Susini, 13388 Marseille, Cedex 13, France.
Behav Brain Res. 2001 Jun;121(1-2):81-93. doi: 10.1016/s0166-4328(00)00387-9.
Apamin blocks SK channels responsible for long-lasting hyperpolarization following the action potential. Using an olfactory associative task, the effect of an intracerebroventricular 0.3 ng apamin injection was tested on learning and memory. Apamin did not modify the learning of the procedure side of the task or the learning of the odor-reward association. To test reference memory specifically, the rats were trained on a new odor-association problem using the same procedure (acquisition session), and they were tested for retention 24 h later. Apamin injected before or after the acquisition session improved retention of the valence of a new odor pair. Apamin injected before the retention session did not affect the retrieval of the new valence. Thus, the results indicate that the blockage of apamin-sensitive SK channels facilitate consolidation on new-odor-reward association.
蜂毒明肽可阻断负责动作电位后持久超极化的小电导钙激活钾（SK）通道。利用嗅觉联想任务，测试了脑室内注射0.3纳克蜂毒明肽对学习和记忆的影响。蜂毒明肽并未改变任务过程侧的学习或气味-奖励关联的学习。为了专门测试参考记忆，使用相同程序（习得阶段）对大鼠进行新的气味关联问题训练，并在24小时后测试其记忆保持情况。在习得阶段之前或之后注射蜂毒明肽可改善新气味对效价的记忆保持。在记忆保持阶段之前注射蜂毒明肽并不影响新效价的提取。因此，结果表明，阻断对蜂毒明肽敏感的SK通道有助于巩固新的气味-奖励关联。
