细胞色素P450（CYP）1A1、CYP1A2、CYP2E1、谷胱甘肽S-转移酶（GST）M1和GSTT1的基因多态性与日本人群前列腺癌易感性的关系
Genetic polymorphisms in cytochrome P450 (CYP) 1A1, CYP1A2, CYP2E1, glutathione S-transferase (GST) M1 and GSTT1 and susceptibility to prostate cancer in the Japanese population.
作者信息
Murata M, Watanabe M, Yamanaka M, Kubota Y, Ito H, Nagao M, Katoh T, Kamataki T, Kawamura J, Yatani R, Shiraishi T
机构信息
Second Department of Pathology, Mie University School of Medicine, 2-174 Edobashi, Tsu, 514, Mie, Japan.
出版信息
Cancer Lett. 2001 Apr 26;165(2):171-7. doi: 10.1016/s0304-3835(01)00398-6.
Associations between genetic polymorphisms of CYP1A1, CYP1A2, CYP2E1, GSTM1 and GSTT1 and prostate cancer (PCa) were analyzed in a case-control study of 315 individuals. The frequency of valine (Val)/valine (Val) genotypes for CYP1A1 was 11.3% in cases compared with 5.5% in controls, this polymorphism thus being associated with a significantly increased risk of PCa (odds ratio=2.4, 95% confidence interval (CI)=1.01-5.57). No links were detected between PCa and polymorphisms in other enzymes. However, the combination of CYP1A1 (Ile/Val and/or Val/Val) polymorphisms with the GSTM1 null type resulted in an OR of 2.2 (CI=1.10-4.57, 1.12-4.20, respectively). This study suggests that the CYP1A1 polymorphism and its combination with GSTM1 may be associated with PCa susceptibility in the Japanese population.
在一项针对315名个体的病例对照研究中，分析了细胞色素P450 1A1（CYP1A1）、细胞色素P450 1A2（CYP1A2）、细胞色素P450 2E1（CYP2E1）、谷胱甘肽S-转移酶M1（GSTM1）和谷胱甘肽S-转移酶T1（GSTT1）的基因多态性与前列腺癌（PCa）之间的关联。CYP1A1的缬氨酸（Val）/缬氨酸（Val）基因型在病例组中的频率为11.3%，而在对照组中为5.5%，因此这种多态性与PCa风险显著增加相关（优势比=2.4，95%置信区间（CI）=1.01-5.57）。未检测到PCa与其他酶的多态性之间存在关联。然而，CYP1A1（异亮氨酸/缬氨酸（Ile/Val）和/或缬氨酸/缬氨酸（Val/Val））多态性与GSTM1无效型的组合导致优势比分别为2.2（CI=1.10-4.57，1.12-4.20）。这项研究表明，CYP1A1多态性及其与GSTM1的组合可能与日本人群的PCa易感性相关。
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