一种四氢异喹啉生物碱氧化产物的色谱分离与光谱鉴定

Chromatographic separation and spectrometric identification of the oxidation products from a tetrahydro-isoquinoline alkaloid.

作者信息

Zhang F, Dryhurst G

机构信息

Analytical R&D, Skin Research Center, Johnson & Johnson Consumer Products Worldwide, Skillman, New Jersey 08558, USA.

出版信息

J Pharm Biomed Anal. 2001 May;25(2):181-9. doi: 10.1016/s0731-7085(00)00472-6.

DOI:10.1016/s0731-7085(00)00472-6

PMID:11275426

Abstract

The oxidation chemistry of 3',4'-deoxynorlaudanosoline carboxylic acid, a tetrahydroisoquinoline alkaloid, has been studied by electrochemical approaches. Four reaction products were isolated by semi-preparative high performance liquid chromatography and identified structurally by nuclear magnetic resonance, mass spectrometry, ultraviolet-visible spectrophotometry and electrochemistry studies. An oxidation mechanism was proposed.

摘要

通过电化学方法研究了四氢异喹啉生物碱3',4'-脱氧去甲劳丹索林羧酸的氧化化学。通过半制备高效液相色谱法分离出四种反应产物，并通过核磁共振、质谱、紫外可见分光光度法和电化学研究对其结构进行了鉴定。提出了一种氧化机理。