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四氢异喹啉类的神经毒性作用及其机制。

Neurotoxic effects of tetrahydroisoquinolines and underlying mechanisms.

机构信息

College of Pharmacy, Seoul National University, Seoul 151-742, Korea.

出版信息

Exp Neurobiol. 2010 Sep;19(2):63-70. doi: 10.5607/en.2010.19.2.63. Epub 2010 Sep 30.

DOI:10.5607/en.2010.19.2.63
PMID:22110343
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3214777/
Abstract

Tetrahydropapaveroline (THP), a neurotoxic tetrahydroisoquinoline alkaloid formed by condensation between dopamine and dopaldehyde, has been speculated to cause Parkinson's disease and also to contribute to alcohol dependence. Having two catechol moieties, THP may readily undergo oxidation to form an o-quinone intermediate with concomitant production of reactive oxygen species, which can cause neuronal cell death and DNA damage. This review will deal with the current knowledge of neurotoxic effects of this endogenous alkaloid and underlying biochemical mechanisms.

摘要

四氢原小檗碱（THP）是一种由多巴胺和邻位二羟苯甲醛缩合形成的神经毒性四氢异喹啉生物碱，被推测可导致帕金森病，并可能导致酒精依赖。由于含有两个儿茶酚结构部分，THP 可能容易发生氧化，形成邻醌中间产物，同时产生活性氧，从而导致神经元细胞死亡和 DNA 损伤。本文将综述这种内源性生物碱的神经毒性作用及其潜在生化机制的现有知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f5/3214777/4fb38adc1dad/en-19-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f5/3214777/4fb38adc1dad/en-19-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f9f5/3214777/4fb38adc1dad/en-19-63-g001.jpg

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