Luke J
School of Biological Sciences, University of Surrey, Guildford, UK.
Caries Res. 2001 Mar-Apr;35(2):125-8. doi: 10.1159/000047443.
The purpose was to discover whether fluoride (F) accumulates in the aged human pineal gland. The aims were to determine (a) F-concentrations of the pineal gland (wet), corresponding muscle (wet) and bone (ash); (b) calcium-concentration of the pineal. Pineal, muscle and bone were dissected from 11 aged cadavers and assayed for F using the HMDS-facilitated diffusion, F-ion-specific electrode method. Pineal calcium was determined using atomic absorption spectroscopy. Pineal and muscle contained 297+/-257 and 0.5+/-0.4 mg F/kg wet weight, respectively; bone contained 2,037+/-1,095 mg F/kg ash weight. The pineal contained 16,000+/-11,070 mg Ca/kg wet weight. There was a positive correlation between pineal F and pineal Ca (r = 0.73, p<0.02) but no correlation between pineal F and bone F. By old age, the pineal gland has readily accumulated F and its F/Ca ratio is higher than bone.
目的是探究氟（F）是否会在老年人类松果体中蓄积。目标是测定：（a）松果体（湿重）、相应肌肉（湿重）和骨骼（灰重）中的氟浓度；（b）松果体中的钙浓度。从11具老年尸体上解剖取出松果体、肌肉和骨骼，采用六甲基二硅氮烷（HMDS）促进扩散、氟离子特异性电极法测定其中的氟含量。使用原子吸收光谱法测定松果体中的钙含量。松果体和肌肉中氟含量分别为297±257和0.5±0.4毫克/千克湿重；骨骼中氟含量为2037±1095毫克/千克灰重。松果体中钙含量为16000±11070毫克/千克湿重。松果体中的氟与钙呈正相关（r = 0.73，p<0.02），但松果体中的氟与骨骼中的氟无相关性。到老年时，松果体已容易蓄积氟，且其氟/钙比值高于骨骼。
