Ueki H, Omori K
Department of Dermatology. Kawasaki Medical School. Matshushima Str. 577, Kurashiki 701-0192, Japan.
Eur J Dermatol. 2001 Mar-Apr;11(2):127-30.
We observed a 26-year-old female patient with discoid lupus erythematosus on her left cheek skin, where fine fragments of windshield glass had been embedded in an automobile accident 8 years previously. She gradually developed general fatigue, morning stiffness of fingers and anti-nuclear antibody. As an etio-pathogenesis of this patient, we speculate that a long exposure to quartz (silica) could give rise to discoid lupus erythematosus in only local damaged areas and at the same time induce systemic immunological changes in some genetically restricted persons; such as production of anti-nuclear antibody. Silica has multi-potential biological effects, especially on immunological functions.
我们观察了一名26岁的女性患者，其左脸颊皮肤患有盘状红斑狼疮，8年前在一次汽车事故中，挡风玻璃的细小碎片嵌入了此处。她逐渐出现全身疲劳、手指晨僵和抗核抗体。关于该患者的病因发病机制，我们推测长期接触石英（二氧化硅）可能仅在局部受损区域引发盘状红斑狼疮，同时在一些具有遗传易感性的人身上诱发全身免疫变化，比如抗核抗体的产生。二氧化硅具有多种潜在的生物学效应，尤其是对免疫功能的影响。
