甲状腺激素在应激诱导心肌热休克蛋白合成中的作用。
Role of thyroid hormones in stress-induced synthesis of heat-shock proteins in the myocardium.
作者信息
Gorodetskaya I V, Bozhko A P, Bakhtina L Y, Malyshev I Y
机构信息
Laboratory of Molecular Mechanisms of Adaptation, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
出版信息
Bull Exp Biol Med. 2000 Dec;130(12):1138-40.
PMID:11276303
Abstract
Thyroxine in near-physiological doses increased the content of heat-shock proteins in the myocardium and stimulated their accumulation during immobilization stress. Blockade of thyroid functions with methimazole decreased the content of heat-shock proteins in rat myocardium during stress and heat shock and prevented their accumulation during adaptation to short-term immobilizations.
摘要
接近生理剂量的甲状腺素可增加心肌中热休克蛋白的含量，并在制动应激期间刺激其积累。用甲巯咪唑阻断甲状腺功能可降低应激和热休克期间大鼠心肌中热休克蛋白的含量，并在适应短期制动期间阻止其积累。
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