[Adaptation of the body to stress effects increases resistance of nuclear DNA of cardiac cells due to accumulation of heat shock proteins in the nucleus].
作者信息
Malyshev I Iu, Zamotrinskiĭ A V, Meerson F Z
出版信息
Biull Eksp Biol Med. 1991 Aug;112(8):126-8.
PMID:1786366
Abstract
It was shown that adaptation to stress exposure increased the resistance of nuclear DNA in myocardial cells to the damaging action of exogenous one-chain DNA (50 micrograms/ml). This protective effect was accompanied by a pronounced accumulation of heat shock proteins (hsp) 70 in nucleoplasm of myocardial cells from adapted animals. Possible mechanism of the DNA protective effect of adaptation and the role of hsp 70 are under discussion.
摘要
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