体育锻炼对磺胺二甲嘧啶乙酰化率的影响。
Effect of physical training on sulfamethazine acetylation rate.
作者信息
Abzalov R A, Nigmatullina R R, Khairullina G N, Garmonov S Y, Shakirova L S, Evgen'ev M I
机构信息
Pedagogical University; Technology University, Kazan'.
出版信息
Bull Exp Biol Med. 2000 Dec;130(12):1141-3.
We studied the rate of sulfamethazine acetylation in athletes and untrained controls aging 18-22 years. The rate of sulfamethazine acetylation in controls was characterized by a bimodal distribution: rapid and slow acetylators constituted 42 and 58%, respectively. The rate of sulfamethazine biotransformation in athletes was characterized by a trimodal distribution: ultrarapid, rapid, and slow xenobiotic acetylators constituted 48.4, 22.6, and 29%, respectively. The ultrarapid acetylation phenotype was probably associated with N-acetyltransferase induction and reflected adaptation to physical exercises
我们研究了18至22岁运动员和未经训练的对照组中磺胺二甲嘧啶的乙酰化速率。对照组中磺胺二甲嘧啶的乙酰化速率呈现双峰分布：快速乙酰化者和慢速乙酰化者分别占42%和58%。运动员中磺胺二甲嘧啶的生物转化速率呈现三峰分布：超快速、快速和慢速外源性物质乙酰化者分别占48.4%、22.6%和29%。超快速乙酰化表型可能与N-乙酰转移酶诱导有关，并反映了对体育锻炼的适应。
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