[慢性酗酒者体内的乙酰化过程]
[Acetylation processes in chronic alcoholics].
作者信息
Kovalev I E, Kovalev E N, Seleznev N G
出版信息
Zh Nevropatol Psikhiatr Im S S Korsakova. 1984;84(2):232-4.
PMID:6711211
Abstract
The activity of N-acetyltransferase was investigated in chronic alcoholics by the intensity of sulfadimezine acetylation. The activity of the enzyme was shown to vary with the stage of the disease. As compared with control, patients with Stage II disease exhibited the predominance of "rapid" acetylators (60%) whilst a significant fall in the number of "rapid" acetylators (from 60% to 36%) was detected in Stage II disease.
摘要
通过磺胺二甲嘧啶乙酰化强度研究了慢性酒精中毒患者体内N - 乙酰转移酶的活性。结果显示，该酶的活性随疾病阶段而变化。与对照组相比，Ⅱ期疾病患者中“快速”乙酰化者占优势（60%），而在Ⅲ期疾病中检测到“快速”乙酰化者数量显著下降（从60%降至36%）。 （注：原文中Stage II和Stage II disease表述疑似有误，推测应为Stage II和Stage III disease，译文按此推测翻译）
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