Ortner M
Endoscopy Unit, Department of Gastroenterology/Hepatology/Endocrinology, Medical Faculty Charité, Campus Mitte, Humboldt University, Schumannstrasse 20-21, D-10117 Berlin, Germany.
Curr Gastroenterol Rep. 2001 Apr;3(2):154-9. doi: 10.1007/s11894-001-0013-8.
Biliary tract cancers are rare malignancies usually characterized by slow growth and a low propensity for metastasis. Despite the relatively localized nature of these cancers, the only therapeutic measure with curative potential to date is surgical intervention. Because symptoms occur late, the diagnosis is rarely made at an early stage, and therefore only about half of the patients can have curative surgery. Patients with advanced disease face a dismal prognosis because palliative treatment options are limited. This review outlines recent advances in treatment of biliary cancer. Encouraging results from prospective, single-arm phase II trials of photodynamic therapy in nonresectable cholangiocarcinoma suggest considerable promise for this new palliative treatment modality. However, the apparent benefit of photodynamic therapy on survival, jaundice, and quality of life must be confirmed in a randomized multicenter trial.
胆道癌是罕见的恶性肿瘤，通常具有生长缓慢和转移倾向低的特点。尽管这些癌症相对局限，但迄今为止唯一具有治愈潜力的治疗措施是手术干预。由于症状出现较晚，很少能在早期作出诊断，因此只有约一半的患者能够接受根治性手术。晚期疾病患者的预后很差，因为姑息治疗选择有限。本综述概述了胆管癌治疗的最新进展。在不可切除胆管癌的前瞻性单臂II期光动力治疗试验中取得的令人鼓舞的结果表明，这种新的姑息治疗方式具有很大的前景。然而，光动力治疗对生存、黄疸和生活质量的明显益处必须在一项随机多中心试验中得到证实。
