Ramos F, Baglivo H P, Ramírez A J, Sánchez R
Hypertension Section, ICYCC, Favaloro Foundation, Favaloro University, Belgrano 1746, Buenos Aires, Argentina.
Curr Hypertens Rep. 2001 Apr;3(2):100-6. doi: 10.1007/s11906-001-0020-z.
The metabolic syndrome is a complex association of several risk factors including insulin resistance, dyslipidemia, and essential hypertension. Insulin resistance has been associated with sympathetic activation and endothelial dysfunction, which are the main mechanisms involved in the pathophysiology of hypertension and its related cardiovascular risk. According to the Sixth Report of the Joint National Committee, and guidelines of the World Health Organization/International Society of Hypertension, the presence of multiple risk markers suggests that both hypertension and risk factors should be aggressively managed in order to obtain a better outcome. Primary prevention of obesity at different levels--individual, familial, and social-- starting early in childhood has proven to be cost effective, and will be mandatory to reduce the world epidemic of obesity and its severe consequences.
代谢综合征是多种危险因素的复杂组合，包括胰岛素抵抗、血脂异常和原发性高血压。胰岛素抵抗与交感神经激活和内皮功能障碍有关，而这是高血压及其相关心血管风险病理生理学中的主要机制。根据美国国家联合委员会第六次报告以及世界卫生组织/国际高血压学会的指南，多种风险标志物的存在表明，应积极控制高血压和危险因素，以获得更好的结果。从儿童早期开始，针对个人、家庭和社会不同层面进行肥胖的一级预防已被证明具有成本效益，对于减少全球肥胖流行及其严重后果将是必不可少的。
