Fisics-Incor牛心包生物假体：15年随访结果。

Fisics-Incor bovine pericardial bioprostheses: 15 year results.

作者信息

Pomerantzeff P M, Brandao C M, Cauduro P, Puig L B, Grinberg M, Tarasoutchi F, Cardoso L F, Lerner A, Stolf N A, Verginelli G, Jatene A D

机构信息

Heart Institute, Hospital das Clínicas, Medical School, University of São Paulo, São Paulo, Brazil.

出版信息

Heart Surg Forum. 1998;1(2):130-5.

PMID:11276451

Abstract

BACKGROUND

From March 1982 to December 1995, 2,607 Fisics-Incor bovine pericardial bioprostheses were implanted in 2,259 patients. Mean age was 47.2 +/- 17.5 years, and 55% were male. Rheumatic fever was present in 1,301 (45.7%) patients.

METHODS

One thousand and seventy-three aortic valve replacements, 1,085 mitral replacements, 27 tricuspid replacements, 195 mitral-aortic replacements, and 16 other combined valve replacements were carried out. Combined procedures were performed in 788 (32.9%) patients, the most frequent being tricuspid valve repair (9.2%) and coronary artery bypass grafting (7.7%).

RESULTS

Hospital mortality was 8.6% (194 patients), 8.6% for the mitral group, 4.7% for the aortic group, and 12.8% for double-valve replacements. The linear rates for calcification, thromboembolism, rupture, leak and endocarditis were, respectively, 1.1%, 0.2%, 0.9%, 0.1% and 0.5% patient-year. The actuarial survival curve was 56.7 +/- 5.4% in 15 years. Survival free from endocarditis was 91.92%, survival free from thromboembolism was 95 +/- 1.7%, survival free from rupture was 43.7 +/- 9.8%, survival free from leak was 98.9 +/- 4.5%, and survival free from calcification was 48.8 +/- 7.9% in 15 years. In the late postoperative period, 1,614 (80.6%) patients were in New York Heart Association functional Class I.

CONCLUSIONS

We conclude that the results with the Fisics-Incor bovine pericardial prostheses were satisfactory in our group of patients.

摘要

背景

1982年3月至1995年12月，2259例患者植入了2607枚Fisics-Incor牛心包生物假体。平均年龄为47.2±17.5岁，55%为男性。1301例（45.7%）患者有风湿热病史。

方法

实施了1073例主动脉瓣置换术、1085例二尖瓣置换术、27例三尖瓣置换术、195例二尖瓣-主动脉瓣置换术以及16例其他联合瓣膜置换术。788例（32.9%）患者接受了联合手术，最常见的是三尖瓣修复（9.2%）和冠状动脉搭桥术（7.7%）。

结果

医院死亡率为8.6%（194例患者），二尖瓣组为8.6%，主动脉瓣组为4.7%，双瓣置换组为12.8%。钙化、血栓栓塞、破裂、渗漏和心内膜炎的年发生率分别为1.1%、0.2%、0.9%、0.1%和0.5%。15年的精算生存曲线为56.7±5.4%。15年无心内膜炎生存率为91.92%，无血栓栓塞生存率为95±1.7%，无破裂生存率为43.7±9.8%，无渗漏生存率为98.9±4.5%，无钙化生存率为48.8±7.9%。术后晚期，1614例（80.6%）患者纽约心脏协会心功能分级为I级。