Jansen J A, den Braber E T, Walboomers X F, de Ruijter J E
Department of Biomaterials, College of Dental Science, Medical Faculty, University of Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Adv Dent Res. 1999 Jun;13:57-66. doi: 10.1177/08959374990130011601.
The applicability of a biomaterial for the manufacturing of oral implants is determined by its physicochemical and geometric surface properties. Research, therefore, is concerned with the cellular reactions that occur when an implant material comes into contact with body tissues. For permucosal oral implants, this involves both the reaction of bone and gingival cells. In vitro cell culturing--including the use of various analytical techniques like light microscopy, scanning and transmission electron microscopy, confocal laser scanning microscopy, and digital image analysis--is a good tool whereby investigators can obtain more insight into the relevant components of implant-tissue adhesion. In the current overview, the role of cell models in oral implant research is discussed, specifically with reference to responses of epithelial cells and fibroblasts.
生物材料在口腔种植体制造中的适用性取决于其物理化学和几何表面特性。因此，研究关注的是植入材料与身体组织接触时发生的细胞反应。对于穿黏膜口腔种植体，这涉及骨细胞和牙龈细胞的反应。体外细胞培养——包括使用各种分析技术，如光学显微镜、扫描和透射电子显微镜、共聚焦激光扫描显微镜和数字图像分析——是一种很好的工具，研究人员可以借此更深入地了解植入物与组织粘附的相关成分。在本综述中，讨论了细胞模型在口腔种植研究中的作用，特别是上皮细胞和成纤维细胞的反应。
