Tanzer F, Hizel S, Cetinkaya O, Sekreter E
Cumhuriyet University, Faculty of Medicine, Sivas.
Int J Vitam Nutr Res. 2001 Jan;71(1):66-9. doi: 10.1024/0300-9831.71.1.66.
Iron deficiency anemia and hyperlipidemia are common public health problems in Turkey. The connection between iron and lipid metabolisms has not been clarified yet. The aim of the study was to determine the effect of iron deficiency on carnitine and lipid metabolism. Study group was consisted of 70 children (mean age 14.7 +/- 1.3 months) suffering from iron deficiency anemia and 20 healthy children (mean age 13.7 +/- 1.2 months) attended to outpatient clinics of Cumhuriyet University, Sivas were enrolled the study as the control group. Assessments of serum free carnitine concentrations, total triglyceride, total cholesterol and VLDL levels were made in both groups. The mean serum free carnitine concentration was significantly lower than the control group (18.9 +/- 0.43 nmol/ml and 45.9 +/- 1.47 nmol/ml respectively, t = 17.5 p < 0.01). Results of our study also indicated higher serum total triglyceride, total cholesterol and VLDL levels in iron deficient patients than the healthy controls. Regression analyses indicated a negative correlation between serum free carnitine and total triglyceride levels in iron deficient patients. This study confirms that iron deficiency anemia may be linked to the endogenous carnitine synthesis in pediatric age group, and thus hyperlipidemia appears to be a risk factor for premature cardiovascular diseases.
缺铁性贫血和高脂血症是土耳其常见的公共卫生问题。铁代谢与脂质代谢之间的联系尚未明确。本研究的目的是确定缺铁对肉碱和脂质代谢的影响。研究组由70名患有缺铁性贫血的儿童（平均年龄14.7±1.3个月）组成，20名健康儿童（平均年龄13.7±1.2个月）作为对照组，这些健康儿童来自锡瓦斯的居米什亚尔大学门诊。对两组儿童的血清游离肉碱浓度、总甘油三酯、总胆固醇和极低密度脂蛋白水平进行了评估。研究组血清游离肉碱平均浓度显著低于对照组（分别为18.9±0.43nmol/ml和45.9±1.47nmol/ml，t = 17.5，p < 0.01）。我们的研究结果还表明，缺铁患者的血清总甘油三酯、总胆固醇和极低密度脂蛋白水平高于健康对照组。回归分析表明，缺铁患者血清游离肉碱与总甘油三酯水平呈负相关。本研究证实，缺铁性贫血可能与儿童年龄组内源性肉碱合成有关，因此高脂血症似乎是过早发生心血管疾病的一个危险因素。
