Four patients with AL amyloidosis treated with high-dose chemotherapy and autologous stem cell transplantation.

作者信息

Reich G, Held T, Siegert W, Kampf D, Dörken B, Maschmeyer G

机构信息

Charité University Hospital, Department of Haematology, Oncology and Tumour Immunology, Humboldt University of Berlin, Germany.

出版信息

Bone Marrow Transplant. 2001 Feb;27(3):341-3. doi: 10.1038/sj.bmt.1702766.

Four patients with AL amyloidosis underwent high-dose chemotherapy and autologous stem cell transplantation at our institutions. Here, we report the clinical courses and outcomes in these patients. Two patients with multi-organ amyloid deposits including cardiac involvement died within 12 days after high-dose chemotherapy. However, in the other two patients, one of whom was suffering from amyloid-related cardiac failure, a significant improvement of organ function was achieved.