1,4-双（4-氟苯基）-2-丙炔基-N-环辛基氨基甲酸酯三个剂量水平对雄性斯普拉格-道利大鼠和F344大鼠的致癌性
Carcinogenicity of three dose levels of 1,4-Bis(4-fluorophenyl)-2-propynyl-N-cyclooctyl carbamate in male Sprague-Dawley and F344 rats.
作者信息
Weisburger E K, Ulland B M, Schueler R L, Weisburger J H, Harris P N
出版信息
J Natl Cancer Inst. 1975 Apr;54(4):975-9.
PMID:1127726
Abstract
Feeding 1,4-bis(fluorophenyl)-2-propynyl-N-cyclooctyl carbamate to F344 or Sprague-Dawley male rats at 125-500 ppm in the diet led to many carcinomas of the small intestine and ear duct (Zymbal's gland tumors) in addition to lymphomas and leukemias. A high incidence of mammary adenocarcinomas was found in the Sprague-Dawley rats. Only a few colon or liver tumors were observed in each strain.
摘要
在饮食中以125 - 500 ppm的剂量给F344或斯普拉格-道利雄性大鼠喂食1,4 - 双（氟苯基）-2 - 丙炔基-N - 环辛基氨基甲酸酯，除了淋巴瘤和白血病外，还导致小肠和耳道（齐默尔氏腺肿瘤）出现许多癌。在斯普拉格-道利大鼠中发现了高发性乳腺腺癌。在每个品系中仅观察到少数结肠或肝脏肿瘤。
Zotero 插件