Yigitbasi O G, Guney E, Haghighi N, Dogan P, Saraymen R, Balkanli S
Dept. of Otorhinolaryngology, Erciyes University, School of Medicine, Kayseri, Turkey.
J Exp Clin Cancer Res. 2000 Dec;19(4):447-51.
In this study we reviewed 20 patients with laryngeal squamous cell carcinoma to evaluate the oxidant and antioxidant status on tissue level. Superoxide Dismutase (SOD) and Catalase levels, two important antioxidant enzymes, and Malondialdehyde (MDA) levels, a valuable index of lipid peroxidation, were compared in cancerous and normal tissues of the patients. In cancerous tissue SOD activities were significantly lower than in the normal tissue, while there was no significant difference in MDA levels and Catalase activities. It was also observed that SOD activities significantly decreased as the histopathologic malignancy grades increased in cancerous tissue. These changes in oxidant and antioxidant status in carcinomatous tissue of the larynx are considered to be of great interest.
在本研究中，我们回顾了20例喉鳞状细胞癌患者，以评估组织水平上的氧化剂和抗氧化剂状态。比较了患者癌组织和正常组织中两种重要的抗氧化酶超氧化物歧化酶（SOD）和过氧化氢酶水平，以及脂质过氧化的重要指标丙二醛（MDA）水平。癌组织中的SOD活性显著低于正常组织，而MDA水平和过氧化氢酶活性无显著差异。还观察到，随着癌组织中组织病理学恶性程度分级的增加，SOD活性显著降低。喉部癌组织中氧化剂和抗氧化剂状态的这些变化被认为具有重要意义。
