Yilmaz Yavuz Fuat, Akbiyik Filiz, Tuncel Umit, Unal Adnan
Department of Otolaryngology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Kulak Burun Bogaz Ihtis Derg. 2007;17(2):81-4.
Reactive oxygen species (ROS) play an important role in the pathogenesis of cancer. The aim of this study was to investigate the extent of lipid peroxidation and ROS in laryngeal cancer tissues.
We determined glutathione (GSH) and malondialdehyde (MDA) activities as markers of lipid peroxidation in laryngeal tumor specimens and tumor-free adjacent tissues of 30 patients with squamous cell carcinoma.
Compared to the tumor-free specimens, the level of GSH was significantly low (p<0.001) whereas MDA, a lipid peroxidation product, showed a significant increase (p<0.01) in cancer tissues. No significant differences were found in MDA and GSH levels between patients with early (n=14) and advanced (n=16) tumor stages (p>0.05).
Decreased antioxidant capacity of laryngeal cancer tissues results in elevation of free oxygen radicals and increased lipid peroxidation. Free radical metabolism may be involved in the pathogenesis of laryngeal cancers.
活性氧（ROS）在癌症发病机制中起重要作用。本研究旨在调查喉癌组织中脂质过氧化和ROS的程度。
我们测定了30例鳞状细胞癌患者喉肿瘤标本及无肿瘤相邻组织中谷胱甘肽（GSH）和丙二醛（MDA）的活性，作为脂质过氧化的标志物。
与无肿瘤标本相比，癌组织中GSH水平显著降低（p<0.001），而脂质过氧化产物MDA则显著升高（p<0.01）。早期（n=14）和晚期（n=16）肿瘤分期患者的MDA和GSH水平无显著差异（p>0.05）。
喉癌组织抗氧化能力下降导致自由基升高和脂质过氧化增加。自由基代谢可能参与喉癌的发病机制。
