Murray P J, Kranz M, Ladlow M, Taylor S, Berst F, Holmes A B, Keavey K N, Jaxa-Chamiec A, Seale P W, Stead P, Upton R J, Croft S L, Clegg W, Elsegood M R
Glaxo Wellcome Cambridge Chemistry Laboratory, UK.
Bioorg Med Chem Lett. 2001 Mar 26;11(6):773-6. doi: 10.1016/s0960-894x(01)00049-x.
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosoma brucei and low mammalian cell toxicity.
描述了一种新的合成策略，可用于制备抗疟真菌代谢产物阿皮西丁的类似物。与天然产物相比，一种类似物在体外对布氏锥虫寄生虫显示出强效和选择性活性，且对哺乳动物细胞毒性较低。
