St Jude Children's Hospital, Department of Chemical Biology and Therapeutics, 262 Danny Thomas Place, Memphis, TN 38105-3678, USA.
Bioorg Med Chem Lett. 2010 Jan 1;20(1):149-52. doi: 10.1016/j.bmcl.2009.11.022. Epub 2009 Nov 14.
A series of halo-nitrobenzamide were synthesized and evaluated for their ability to block proliferation of Trypanosoma brucei brucei. A number of these compounds had significant activity against the parasite, particularly 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide 17 which exhibited low micromolar inhibitory potency against T. brucei and selectivity towards both malaria and mammalian cells.
一系列卤代硝基苯甲酰胺被合成并评估其抑制布氏冈比亚锥虫增殖的能力。这些化合物中有许多对寄生虫具有显著的活性，特别是 2-氯-N-(4-氯苯基)-5-硝基苯甲酰胺 17，它对 T. brucei 表现出低微摩尔抑制效力，并对疟疾和哺乳动物细胞具有选择性。
