Samuel M, Ceballos-Baumann A O, Boecker H, Brooks D J
MRC Clinical Sciences Centre, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital, London, UK.
Neuroreport. 2001 Mar 26;12(4):821-8. doi: 10.1097/00001756-200103260-00040.
Motor imagery paradigms can be used to investigate motor preparation. We used positron emission tomography to compare regional cerebral blood flow (rCBF) in patients with Parkinson's disease and normal controls under three conditions: rest, motor imagery and motor execution. In controls, imagery activated bilateral dorsolateral and mesial frontal cortex, inferior parietal cortex and precuneus. Motor execution additionally activated primary motor cortex (p < 0.001). Between-group, for imagery there was relative reduction in dorsolateral and mesial frontal activation in the patient group (p<0.01). For execution, there was impaired activation of right dorsolateral frontal cortex and basal ganglia (p<0.01). Our results support the notion that underfunctioning of mesial frontal and dorsolateral prefrontal cortex may underlie motor preparation in Parkinson's disease but also suggest that akinesia may occur in the absence of impaired mesial frontal cortex activation.
运动想象范式可用于研究运动准备。我们使用正电子发射断层扫描来比较帕金森病患者和正常对照在三种条件下的局部脑血流（rCBF）：静息、运动想象和运动执行。在对照组中，想象激活了双侧背外侧和内侧额叶皮质、顶下小叶皮质和楔前叶。运动执行还额外激活了初级运动皮质（p<0.001）。组间比较，在想象时，患者组背外侧和内侧额叶激活相对减少（p<0.01）。对于执行，右侧背外侧额叶皮质和基底神经节的激活受损（p<0.01）。我们的结果支持以下观点，即内侧额叶和背外侧前额叶皮质功能不足可能是帕金森病运动准备的基础，但也表明在没有内侧额叶皮质激活受损的情况下可能会出现运动不能。
