Program in Physical Therapy, Washington University in St. Louis, St. Louis, MO 63108, USA.
J Parkinsons Dis. 2012;2(2):127-33. doi: 10.3233/JPD-2012-12077.
Motor imagery during functional magnetic resonance imaging is commonly used to understand the neural underpinnings of complex movements. This approach has recently been applied to individuals with Parkinson disease (PD) to better understand how brain function may relate to movement dysfunction. However, the ability of individuals with PD to imagine movements when "Off" dopamine replacement medication is poorly understood. Therefore, the primary purpose of the current study is to test the ability of people with PD to imagine movements while "On" and "Off" anti-Parkinson medication.
Vividness of imagery was assessed in 28 individuals with mild to moderate PD (Hoehn and Yahr stages 1-3) via the Kinesthetic Visual Imagery Questionnaire (KVIQ-20) both "On" and "Off" anti-Parkinson medication. Vividness of imagery of 32 age-matched older adults was also assessed.
No differences in vividness of imagery were observed between "Off" and "On" medication states (p = 0.15). Imagery was similar between controls and PD both "Off" (p = 0.25) and "On" (p = 0.46) anti-Parkinson medication. A significant correlation was observed between imagery and disease severity while "On" anti-Parkinson medication (r = -0.49; p = 0.008).
Vividness of movement imagery was not different between "Off" and "On" anti-Parkinson medications or between PD and controls. These results suggest that people with PD are able to imagine similarly to older adults both when "On" and "Off" anti-Parkinson medication, and supports the use of motor imagery in the "Off" medication state.
功能磁共振成像中的运动想象通常用于了解复杂运动的神经基础。这种方法最近已应用于帕金森病（PD）患者，以更好地了解大脑功能如何与运动功能障碍相关。然而，人们对 PD 患者在停用多巴胺替代药物时想象运动的能力知之甚少。因此，目前研究的主要目的是测试 PD 患者在服用和不服用抗帕金森药物时想象运动的能力。
通过运动视觉想象问卷（KVIQ-20）评估 28 名轻度至中度 PD 患者（Hoehn 和 Yahr 分期 1-3）在服用和不服用抗帕金森药物时的想象生动度。还评估了 32 名年龄匹配的老年成年人的想象生动度。
在服用和不服用抗帕金森药物状态下，想象的生动度没有差异（p = 0.15）。在服用和不服用抗帕金森药物时，对照组和 PD 患者的想象相似（p = 0.25 和 p = 0.46）。在服用抗帕金森药物时，想象与疾病严重程度之间存在显著相关性（r = -0.49；p = 0.008）。
在服用和不服用抗帕金森药物时，运动想象的生动度在 PD 患者和对照组之间没有差异。这些结果表明，PD 患者在服用和不服用抗帕金森药物时，能够像老年人一样进行相似的想象，支持在停用抗帕金森药物时使用运动想象。
