氧化可他米定，一种来自新西兰担子菌（蘑菇）丝膜菌属物种的新型二硫化物代谢产物。

Cortamidine oxide, a novel disulfide metabolite from the New Zealand basidiomycete (mushroom) Cortinarius species.

作者信息

Nicholas G M, Blunt J W, Munro M H

机构信息

Department of Chemistry, University of Canterbury, PB 4800, Christchurch, New Zealand.

出版信息

J Nat Prod. 2001 Mar;64(3):341-4. doi: 10.1021/np000408+.

DOI:10.1021/np000408+

PMID:11277751

Abstract

Three disulfide metabolites were isolated from the fruiting bodies of the basidiomycete (mushroom) Cortinarius sp., collected in the Catlins, New Zealand. The structures of these compounds were determined as the unsymmetrical disulfide cortamidine oxide (1), 2,2'-dithiobis(pyridine N-oxide) (2), and the symmetrical disulfide 3. Both 1 and 2 showed significant antimicrobial activity and cytotoxicity. 2,2'-Dithiobis(pyridine N-oxide) (2) and the symmetrical disulfide 3 are assumed to be artifacts of the isolation procedure.

摘要

从采集于新西兰卡特林斯地区的担子菌（蘑菇）丝膜菌属真菌的子实体中分离出了三种二硫化物代谢产物。这些化合物的结构被确定为不对称二硫化物氧化皮质脒（1）、2,2'-二硫代双（吡啶 N-氧化物）（2）和对称二硫化物 3。化合物 1 和 2 均表现出显著的抗菌活性和细胞毒性。2,2'-二硫代双（吡啶 N-氧化物）（2）和对称二硫化物 3 被认为是分离过程中的人为产物。