来自冲绳海绵Plakortis lita的细胞毒性内过氧化物——波照间二氧杂环己二烯A和B的分离与结构
Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.
作者信息
Takada N, Watanabe M, Yamada A, Suenaga K, Yamada K, Ueda K, Uemura D
机构信息
Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
出版信息
J Nat Prod. 2001 Mar;64(3):356-9. doi: 10.1021/np0003490.
PMID:11277756
Abstract
Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.
摘要
从冲绳海绵Plakortis lita中分离出了细胞毒性内过氧化物——波照间二氧杂环己二烯A（1）和B（2）。通过光谱分析确定了它们的结构。通过降解反应和改良的莫舍尔法确定了1的绝对立体结构。波照间二氧杂环己二烯对38种人类癌细胞系显示出显著的细胞毒性。
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