Yadid G, Overstreet D H, Zangen A
Faculty of Life Science, Bar-Ilan University, 52900, Ramat-Gan, Israel.
Brain Res. 2001 Mar 30;896(1-2):43-7. doi: 10.1016/s0006-8993(00)03248-0.
The dopaminergic mesolimbic system has a key role in motivation and reward, and stressful stimuli appear to alter its functionality. Since stress is considered to be one of the primary factors that mediate the expression of depressive behavior, dopamine and its metabolites in the nucleus accumbens of control and Flinders Sensitive Line rats, an animal model of depression, were examined prior to and after a forced swim test. In both types of rats, the levels of dopamine metabolites markedly decreased after the forced swimming, albeit to different extents. In contrast, 60 min after the swim test, dopamine levels were elevated only in the control rats. The accumbal dopaminergic activity is discussed in relation to the behavior of 'depressed' and normal rat lines subjected to a stressful event.
多巴胺能中脑边缘系统在动机和奖赏方面起着关键作用，应激刺激似乎会改变其功能。由于应激被认为是介导抑郁行为表达的主要因素之一，因此在强迫游泳试验前后，对对照大鼠和弗林德斯敏感系大鼠（一种抑郁症动物模型）伏隔核中的多巴胺及其代谢产物进行了检测。在两种类型的大鼠中，强迫游泳后多巴胺代谢产物水平均显著下降，尽管下降程度不同。相比之下，游泳试验60分钟后，仅对照大鼠的多巴胺水平升高。结合遭受应激事件的“抑郁”和正常大鼠品系的行为，对伏隔核多巴胺能活性进行了讨论。
