Gupta R, Pathak D, Jindal D P
University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India.
Eur J Med Chem. 1999 Jul-Aug;34(7-8):659-62. doi: 10.1016/s0223-5234(00)80035-5.
4-Aza-5 alpha-androstano[2,3-d]isoxazole 4 and 17a-aza-D-homo-5-androsteno[17,16-c]isoxazole 7 have been prepared by treating alpha,beta-unsaturated-beta-chloroaldehydes 3 and 6 [1, 2] with hydroxylamine hydrochloride in pyridine. [16,17-d]Isoxazole derivatives 4 and 8 were found to be unstable in most of the organic solvents. beta-Cyanolactam derivatives 5 and 9 have also been prepared in both the series.
通过在吡啶中用盐酸羟胺处理α,β-不饱和-β-氯醛3和6 [1,2]制备了4-氮杂-5α-雄甾烷[2,3-d]异恶唑4和17α-氮杂-D-高-5-雄甾烯[17,16-c]异恶唑7。发现[16,17-d]异恶唑衍生物4和8在大多数有机溶剂中不稳定。还在这两个系列中制备了β-氰基内酰胺衍生物5和9。
