Dubin L, Amelar R D
J Urol. 1975 May;113(5):640-1. doi: 10.1016/s0022-5347(17)59542-7.
During a 10-year period 504 selected subfertile men underwent surgical correction of varicocele and had a followup of at least 1 year. Improved semen quality was reported in 71 per cent of the men and 55 per cent of the wives became pregnant. Statistically, results were better in terms of semen quality improvement and pregnancy in patients who had preoperative sperm counts greater than 10 million per cc (88 per cent improved, 68 per cent pregnant) compared to patients who had preoperative sperm counts of less than 10 million per cc (33 per cent improved, 23 per cent pregnant). The impiric use of postoperative human chorionic gonadotropin therapy in the latter group of patients improves results significantly (56 per cent improved, 44 per cent pregnant).
在10年期间，504名经挑选的不育男性接受了精索静脉曲张手术矫正，并进行了至少1年的随访。71%的男性精液质量得到改善，55%的妻子怀孕。从统计学角度来看，术前精子计数大于每立方厘米1000万的患者，在精液质量改善和怀孕方面的结果更好（88%精液质量改善，68%妻子怀孕），而术前精子计数低于每立方厘米1000万的患者则分别为33%和23%。后一组患者术后经验性使用人绒毛膜促性腺激素治疗可显著改善结果（56%精液质量改善，44%妻子怀孕）。
