Guerrant R L, Carpenter C C
Johns Hopkins Med J. 1975 May;136(5):209-11.
Rapid intravenous saline infusion causes secretion of isotonic fluid by the canine duodenum. The duodenal fluid secretion is not accompanied either by increased adenyl cyclase activity in the mucosal epithelial cells or by widening of the "tight junctions" between epithelial cells. These data clearly indicate that the diarrheagenic effect of volume expansion is not mediated by the adenyl cyclase system. Furthermore, these data provide support for the concept that, when increased mucosal adenyl cyclase activity is associated with gut fluid secretion, the adenyl cyclase stimulation is a primary event, and is not secondary to the transmucosal isotonic fluid movement.
快速静脉输注生理盐水可导致犬十二指肠分泌等渗液。十二指肠液分泌既不伴有黏膜上皮细胞中腺苷酸环化酶活性增加，也不伴有上皮细胞间“紧密连接”增宽。这些数据清楚地表明，容量扩张的致腹泻作用不是由腺苷酸环化酶系统介导的。此外，这些数据支持以下概念：当黏膜腺苷酸环化酶活性增加与肠液分泌相关时，腺苷酸环化酶的刺激是一个原发性事件，而非继发于经黏膜等渗液移动。
