Mueller X M, Tevaearai H T, Ruchat P, Stumpe F, von Segesser L K
Clinic for Cardiovascular Surgery, CHUV (Centre Hospitalier Universitaire Vaudois), CH-1011 Lausanne, Switzerland.
J Thorac Cardiovasc Surg. 2001 Apr;121(4):683-8. doi: 10.1067/mtc.2001.112529.
Atrial fibrillation after coronary artery bypass operations remains frequent and increases morbidity, as well as resource use. Its cause remains unclear. The introduction of a minimally invasive technique provides an opportunity to evaluate the effect of intraoperative factors, such as cardiopulmonary bypass, global myocardial ischemia, and myocardial protection technique, on the occurrence of this arrhythmia.
All the patients undergoing isolated left internal thoracic artery-left anterior descending artery grafting between January 1994 and December 1999 were reviewed. Twenty possible risk factors for postoperative atrial fibrillation, including the choice of operative technique--minimally invasive technique was introduced in January 1997--were entered into univariate and multivariable logistic regression analysis.
Postoperative atrial fibrillation occurred in 36 (20%) of 183 patients. On univariate analysis, age (P <.001) and a history of supraventricular arrhythmia (P <.001) were found to be risk factors. In particular, 15 (22%) of 69 patients operated on with the minimally invasive technique had postoperative atrial fibrillation versus 21 (18%) of 114 in the standard group (P =.58). On multivariable analysis, including the operative technique, the same variables (P =.001 and.01, respectively) were identified as independent risk factors.
The introduction of a minimally invasive technique for coronary artery bypass operations did not reduce the occurrence of postoperative atrial fibrillation in this study population. This suggests that prophylactic measures to reduce this arrhythmia should be focused on factors unrelated to cardiopulmonary bypass or myocardial preservation technique.
冠状动脉搭桥术后房颤仍然频发,会增加发病率以及资源利用。其病因尚不清楚。微创技术的引入提供了一个机会来评估术中因素,如体外循环、全心肌缺血和心肌保护技术,对这种心律失常发生的影响。
回顾了1994年1月至1999年12月期间所有接受单纯左乳内动脉-左前降支搭桥术的患者。将20种可能的术后房颤危险因素,包括手术技术的选择——1997年1月引入了微创技术——纳入单因素和多因素逻辑回归分析。
183例患者中有36例(20%)发生术后房颤。单因素分析发现,年龄(P<.001)和室上性心律失常病史(P<.001)是危险因素。特别是,69例接受微创技术手术的患者中有15例(22%)发生术后房颤,而标准组114例中有21例(18%)(P=.58)。多因素分析包括手术技术,同样的变量(分别为P=.001和.01)被确定为独立危险因素。
在本研究人群中,冠状动脉搭桥手术引入微创技术并未降低术后房颤的发生率。这表明,减少这种心律失常的预防措施应侧重于与体外循环或心肌保护技术无关的因素。