Cookson W O, Ubhi B, Lawrence R, Abecasis G R, Walley A J, Cox H E, Coleman R, Leaves N I, Trembath R C, Moffatt M F, Harper J I
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Nat Genet. 2001 Apr;27(4):372-3. doi: 10.1038/86867.
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.
我们对特应性皮炎（AD）进行了全基因组筛查，已确定1q21、17q25和20p染色体上存在与AD的连锁关系。这些区域与已知的银屑病位点密切对应，之前在3q21染色体上鉴定出的一个AD位点也是如此。结果表明，AD受对皮肤炎症和免疫具有普遍影响的基因影响。
